This paper is intended to stimulate debate amongst stakeholders in the international research community on the topic of returning individual genetic research results to study participants. Pharmacogenetics and disease genetics studies are becoming increasingly prevalent, leading to a growing body of information on genetic associations for drug responsiveness and disease susceptibility with the potential to improve health care. Much of these data are presently characterized as exploratory (non‐validated or hypothesis‐generating). There is, however, a trend for research participants to be permitted (...) access to their personal data if they so choose. Researchers, sponsors, patient advocacy groups, ethics committees and regulatory authorities are consequently confronting the issue of whether, and how, study participants might receive their individual results. Noted international ethico‐legal guidelines and public policy positions in Europe and the United States are reviewed for background. The authors offer ‘Points‐to‐Consider’ regarding returning research results in the context of drug development trials based on their knowledge and experience. These considerations include: the clinical relevance of data, laboratory qualifications, informed consent procedures, confidentiality of medical information and the competency of persons providing results to participants. The discussion is framed as a benefit‐to‐risk assessment to balance the potential positive versus negative consequences to participants, while maintaining the integrity and feasibility of conducting genetic research studies. (shrink)

ABSTRACT This paper is intended to stimulate debate amongst stakeholders in the international research community on the topic of returning individual genetic research results to study participants. Pharmacogenetics and disease genetics studies are becoming increasingly prevalent, leading to a growing body of information on genetic associations for drug responsiveness and disease susceptibility with the potential to improve health care. Much of these data are presently characterized as exploratory (non‐validated or hypothesis‐generating). There is, however, a trend for research participants to be (...) permitted access to their personal data if they so choose. Researchers, sponsors, patient advocacy groups, ethics committees and regulatory authorities are consequently confronting the issue of whether, and how, study participants might receive their individual results. Noted international ethico‐legal guidelines and public policy positions in Europe and the United States are reviewed for background. The authors offer ‘Points‐to‐Consider’ regarding returning research results in the context of drug development trials based on their knowledge and experience. These considerations include: the clinical relevance of data, laboratory qualifications, informed consent procedures, confidentiality of medical information and the competency of persons providing results to participants. The discussion is framed as a benefit‐to‐risk assessment to balance the potential positive versus negative consequences to participants, while maintaining the integrity and feasibility of conducting genetic research studies. (shrink)

Machine learning algorithms may radically improve our ability to diagnose and treat disease. For moral, legal, and scientific reasons, it is essential that doctors and patients be able to understand and explain the predictions of these models. Scalable, customisable, and ethical solutions can be achieved by working together with relevant stakeholders, including patients, data scientists, and policy makers.

Ad hominem arguments are generally dismissed on the grounds that they are not attempts to engage in rational discourse, but are rather aimed at undermining argument by diverting attention from claims made to assessments of character of persons making claims. The manner of this dismissal however is based upon an unlikely paradigm of rationality: it is based upon the presumption that our intellectual capacities are not as limited as in fact they are, and do not vary as much as they (...) do between rational people. When we understand rationality in terms of intellectual virtues, however, which recognize these limitations and provide for the complexity of our thinking, ad hominem considerations can sometimes be relevant to assessing arguments. (shrink)

The objective list theory of well-being holds that a plurality of basic objective goods directly benefit people. These can include goods such as loving relationships, meaningful knowledge, autonomy, achievement, and pleasure. The objective list theory is pluralistic (it does not identify an underlying feature shared by these goods) and objective (the basic goods benefit people independently of their reactive attitudes toward them). In this paper, I discuss the structure of this theory and show how it is supported by people's considered (...) judgments. I then respond to three objections. First, I argue that there is no conceptual reason to favor a monistic theory of well-being over a pluralistic one (such as the objective list theory). Second, I argue that states of affairs can benefit people even though they hold no positive reactive attitudes toward them. And, third, I argue that objective list theorists can identify a fairly-determinate list of basic goods. (shrink)

Ectogestation involves the gestation of a fetus in an ex utero environment. The possibility of this technology raises a significant question for the abortion debate: Does a woman’s right to end her pregnancy entail that she has a right to the death of the fetus when ectogestation is possible? Some have argued that it does not Mathison & Davis. Others claim that, while a woman alone does not possess an individual right to the death of the fetus, the genetic parents (...) have a collective right to its death Räsänen. In this paper, I argue that the possibility of ectogestation will radically transform the problem of abortion. The argument that I defend purports to show that, even if it is not a person, there is no right to the death of a fetus that could be safely removed from a human womb and gestated in an artificial womb, because there are competent people who are willing to care for and raise the fetus as it grows into a person. Thus, given the possibility of ectogestation, the moral status of the fetus plays no substantial role in determining whether there is a right to its death. (shrink)

This article investigates the role of privacy and transparency in the 4th Space and outlines their implications for the development and dissemination of conspiracy theories. We argue that privacy can be exploited by individuals and organizations to spread conspiracy theories online, while organizational transparency, intended to increase accountability and ultimately trust, can have the adverse effect and nurture conspiracy beliefs. Through the lens of the 4th Space concept, we offer suggestions on how to approach those challenges which emerge as a (...) result of the complex entanglements of both actual and virtual world across time. (shrink)

Issues of interest, identity and values intertwine in environmental conflicts, creating challenges that cannot generally be overcome using rationalities grounded in generalised argumentation and abstraction. To address the growing need to engage interests and identities along with plural values in the conservation of biodiversity and ecological systems, we introduce the concept of ‘appropriateness of actions’ and ground it in a relational understanding of environmental ethics. A determination of appropriateness for actions comes from combining outputs from value elicitation with those of (...) interest and identity negotiation in ways that are salient to specific people and their relationships to specific places. Drawing on the Blue Mountain Forest Partnership in the Pacific Northwest, we propose factors of success for supporting appropriate actions: 1) understanding context and identifying key stakeholders; 2) surfacing a diversity of interests and building system-level trust; 3) building empathy for different identities grounded in specific places; 4) eliciting diverse values and seeking to understand their links to worldviews and knowledge systems and; 5) seeking out appropriate actions. (shrink)

What, if anything, directly detracts from well-being? Objective list theorists affirm basic goods such as knowledge, friendship, and achievement, but it is less clear what they should say about opposing bads. In this paper, I argue that false beliefs, unhealthy relationships, and failed projects are not basic bads and do not directly detract from well-being. They can have bad effects or elements, or block the realization of basic goods, but do not themselves carry negative weight with respect to well-being. This (...) is shown by comparing cases where these bads are present and absent, examining their relation to negative overall well-being, and considering the role of these bads in the pursuit of positive goods. (shrink)

In this paper I attempt to show how my graduate work in interpretive studies transformed my previous work as a special education consultant. Using Hans-Georg Gadamer's hermeneutics, as well as Ivan Illich's notions of iatrogenesis and counter-productivity, I discuss my work with a school team as they struggled throughout a school year with a special education classroom for students with diagnosed mental health disorders.

Considers four apparent problems of eternal life--is heaven a mystical or social reality, is it other-worldly or this-worldly, is it static or dynamic, is it boring?--and shows how the teachings of Thomas Aquinas support more satisfying solutions than many contemporary philosophical and theological approaches.

I do four things in responding to Patrick Toner’s incisive critique of my Aquinas and the Ship of Theseus (AST). First, I further motivate Aquinas’s position that Socrates exists in the post-mortem and ante-resurrection state by noting that Socrates’ situation is at least analogous to other states of affairs that would certainly count as atypical (although not impossible). Secondly, I offer a revised Thomistic account of artefact identity through time in light of Toner’s objections to Aquinas’srestrictive view. Unlike the restrictive (...) view, this revised account is compatible with common-sense intuitions. Thirdly, I show how my defense of Aquinas’s substance metaphysic in AST is useful for the purpose of constructing defeators for certain kinds of arguments for reductionism. Fourthly, I defend Aquinas’s views on the unity of substance against Toner’s suggestion that they are implausible on the grounds that they are in conflict with certain so-called “scientifically informed”common-sense beliefs. (shrink)

Over the past 40 years, the sense of place concept has been well-established across a range of applications and settings; however, most theoretical developments have ‘privileged the slow’. Evidence suggests that place attachments and place meanings are slow to evolve, sometimes not matching material or social reality (lag effects), and also tending to inhibit change. Here we present some key blind spots in sense of place scholarship and then suggest how a reconsideration of sense of place as ‘fast’ and ‘slow’ (...) could fill them. By this, we mean how direct and immediate perception-action processes presented in affordance theory (resulting in immediately perceived place meanings) can complement slower forms of social construction presented in sense of place scholarship. Key blind spots are that sense of place scholarship: 1) rarely accounts for sensory or immediately perceived meanings; 2) pays little attention to how place meanings are the joint product of attributes of environmental features and the attributes of the individual; and; 3) assumes that the relationship between place attachment and behaviour is linear and not constituted in dynamic relations among mind, culture and environment.. We show how these blind spots can begin to be addressed by reviewing key insights from affordance theory, and through the presentation of applied examples. We discuss future empirical research directions in terms of: 1) how sense of place is both perceived and socially constructed; 2) whether perceived and socially constructed dimensions of place can relate to one another when perceived meanings become unsituated, and; 3) how place attachment may change over different stages of the life course based upon dynamic relationships between processes of perception-action and social construction. We conclude with insights into how processes of perception-action and social construction could be included in the design and management of urban landscapes. (shrink)

Toward the end of his classic treatise An Essay on Free Will, Peter van Inwagen offers a modal argument against the Principle of Sufficient Reason which he argues shows that the principle “collapses all modal distinctions.” In this paper, a critical flaw in this argument is shown to lie in van Inwagen’s beginning assumption that there is such a thing as the conjunction of all contingently true propositions. This is shown to follow from Cantor’s theorem and a property of conjunction (...) with respect to contingent propositions. Given the failure of this assumption, van Inwagen’s argument against the Principle of Sufficient Reason cannot succeed, at least not without the addition of some remarkable and previously unacknowledged qualifications. (shrink)

In the United States, food banks served an estimated 46 million people in 2015. A combination of government policy reforms and political economic trends contributed to the rising numbers of individuals relying on private food assistance in the US, the United Kingdom and other high-income countries. Although researchers frequently map urban food environments, this project is one of the first to map private food assistance and potential need at the census-tract scale. We utilize Geographic Information Systems, demographic data, and food (...) assistance locations to develop a rapid assessment tool that could support food banks, pantries, soup kitchens, and government agencies that seek to answer the question of whether people with the greatest need have food distribution sites in close proximity. We define access based on distance and then calculate potential food insecurity using either poverty rates or a food insecurity index. We apply these methods in a case study analysis of Santa Clara County, California. Our findings suggest that food assistance distribution locations match the areas of potential need in more than 80% of urban census tracts. However, there are several potentially underserved locations and populations that could benefit from new food assistance operations. The poverty and index-based approaches show significant spatial overlap in mapped areas of high food insecurity and low access. The poverty only approach produces a higher estimate of food insecurity rates, is easier to calculate, and draws attention to the need to address poverty as a root cause of hunger. (shrink)

This paper argues for the claim that the mental ontology required for what has been called the “Phenomenal Intentionality Theory” (PIT) should be understood in terms of mental events or episodes, not mental states that instantiate phenomenal properties because the former but not the latter has a kind of temporal shape. I begin by laying out the basic commitments of PIT. I then introduce the notion of “temporal shape” and defend the following simple but powerful argument: (1) If conscious experiences (...) are phenomenal mental states that instantiate phenomenal properties, then the phenomenal character of these experiences will lack a temporal shape. (2) The phenomenal character of conscious experience typically has a temporal shape. (3) Therefore, conscious experiences are not mental states that instantiate phenomenal properties. (shrink)

Talk therapy is, by definition, difficult, if not impossible, to represent materially. Whereas other scholars have sought to do so by referencing Sigmund Freud’s drawings or the setting of his consulting room, this article looks instead to the use of cloth in Joanne Greenberg’s 1964 semiautobiographical novel I Never Promised You a Rose Garden. The two main treatments given to protagonist Deborah Blau were therapy sessions with Dr. Clara Fried, based on Frieda Fromm-Reichmann, and the “cold pack,” in which the (...) patient was restrained and wrapped in sheets drenched with ice water. The two treatments, this article argues, can be considered in parallel, and through analysis of the material descriptions of the cold pack, one can learn more about the talking cure. Namely, this article analyzes the care in both cases as one of constraint, giving material form to the metaphorical “holding environment” of psychoanalyst D. W. Winnicott. Deborah uses the cold pack to endure her psychosis and return to reality. Similarly, Winnicott describes the ideal therapeutic space as one that, by its reliability, allows regression in service of finding a new self and distinguishing between fantasy and the outside world. The aim of this article is thus twofold: one, to further elucidate the role of cloth in treating mental distress, and two, to understand more fully the therapeutic relationship via the literal and figurative constraint of treatment. (shrink)

In these replies, I shall respond to criticisms offered by Kaczor and Rodger to my article titled “Ectogestation and the Problem of Abortion.” In the process, I shall also try to bring into focus why the possibility of ectogestation will radically alter the shape of the abortion debate.

Kathrin Koslicki argues that ordinary material objects like tables and motorcycles have formal proper parts that structure the material proper parts. Karen Bennett rejects a key premise in Koslicki's argument according to which the material ingredient out of which a complex material object is made is a proper part of that object. Koslicki defends this premise with a principle motivated by its power to explain three important phenomena of material composition. But these phenomena can be equally well explained by a (...) weaker principle that does not support the questioned premise in Koslicki's argument, Bennett argues. I show that Bennett's weaker principle, together with an appropriate strengthening of a different premise in Koslicki's original argument, still yields a sound argument for the existence of formal parts. (shrink)

It may be true that we are epistemically in the dark about various things. Does this fact ground the truth of fallibilism? No. Still, even the most zealous skeptic will probably grant that it is not clear that one can be incognizant of their own occurrent phenomenal conscious mental goings-on. Even so, this does not entail infallibilism. Philosophers who argue that occurrent conscious experiences play an important epistemic role in the justification of introspective knowledge assume that there are occurrent beliefs. (...) But this assumption is false. This paper argues that there are no occurrent beliefs. And it considers the epistemic consequences this result has for views that attempt to show that at least some phenomenal beliefs are infallible. (shrink)

Truth is a locus of guilt for the Christian, according to Jacques Lacan. The religious person, he argues, punitively defers truth eschatologically. Yet Lacan’s own view dissolves eschatological deferral to the world, as the “Real”. The metaphysics of Erich Przywara SJ helps highlight that this mirrors Lacan’s view of the religious person. Przywara’s Christian metaphysics and Lacanian psychoanalysis converge on the immanence of truth to history. But Przywaran analogy corrects Lacan’s position on the religious person, which by implication calls for (...) an adjustment to Lacan’s worldview. In the final analysis, Lacan’s dialectical nihilism should yield to a Christian’s hopeful relation to the truth. (shrink)

In a recent paper, “Incompatiblism, Sin, and Free Will in Heaven,” Timothy Pawl and Kevin Timpe discuss and propose a novel solution to a problem posed for traditional Christian theism that they call the Problem of Heavenly Freedom. In short, Christian tradition contains what seems to be a contradiction, namely, the redeemed in heaven are free but nonetheless can’t sin. Pawl and Timpe’s solution to the Problem of Heavenly Freedom is particularly attractive for two reasons: it shows great respect for (...) the Christian tradition’s teaching on heaven, and it entails that the redeemed in heaven act with morally weighty libertarian free will. Nonetheless, I think their solution can be improved upon. By drawing on some of the teachings of the Catholic tradition on heaven, particularly those of St. Thomas Aquinas, I raise three objections to Pawl and Timpe’s solution and introduce a modified version of their solution. In doing so, I have attempted to make their “best” solution to the Problem of Heavenly Freedom even better. (shrink)

A growing body of evidence suggests that two distinct forms of group alignment are possible: identification and fusion (the former asserts that group and personal identity are distinct, while the latter asserts group and personal identities are functionally equivalent and mutually reinforcing). Among highly fused individuals, group identity taps directly into personal agency and so any attack on the group is perceived as a personal attack and motivates a willingness to fight and possibly even die as a defensive response. As (...) such, identity fusion is relevant in explaining violent extremism, including suicidal terrorist attacks. Identity fusion is theorized to arise as a result from the sharing of personally transformative experiences with other group members, however evidence for this relationship remains limited to date. Here, we present a pre-registered study in which we examine the role of transformativeness and perceived sharedness of group-defining events in generating identity fusion. We find that both of these factors are predictive of identity fusion but that the relationship with transformativeness was more consistent than perceived sharedness across analyses in a sample of Indonesian Muslims. (shrink)